American Society of Microbiology ABMM 認定 ABMM 試験問題:

1. A patient presents with a chronic, non-healing skin ulcer in a tropical region. Microscopic examination of a biopsy reveals amastigotes within macrophages. Culture of the biopsy on Novy-MacNeal-Nicolle (NNN) medium yields flagellated promastigotes. The MOST likely diagnosis is cutaneous leishmaniasis caused by:

A) Trypanosoma brucei gambiense
B) Trypanosoma cruzi
C) Leishmania tropica or Leishmania major
D) Leishmania donovani

2. A patient presents with a chronic cough, weight loss, and night sweats. Chest X-ray shows cavitarylesions in the upper lobes. Sputum is acid-fast positive. Drug susceptibility testing reveals resistance to isoniazid but susceptibility to rifampin, ethambutol, and pyrazinamide. The MOST appropriate treatment regimen should include:

A) Isoniazid, rifampin, pyrazinamide, and ethambutol
B) Isoniazid, ethambutol, and pyrazinamide
C) Isoniazid and rifampin
D) Rifampin, ethambutol, and pyrazinamide

3. A Gram stain of anaerobic growth from a peritoneal fluid abscess reveals pleomorphic, pale-staining Gram- negative rods. The isolate grows on Bacteroides Bile Esculin (BBE) agar, hydrolyzing esculin (producing black colonies), and is resistant to kanamycin (1000 µg), vancomycin (5 µg), and colistin (10 µg) disks. Which organism group is most likely?

A) Fusobacterium nucleatum
B) Bacteroides fragilis group
C) Clostridium perfringens
D) Prevotella melaninogenica group

4. Which biosafety level (BSL) is required for clinical laboratory work involving the propagation (culture) of Coccidioides immitis/posadasii?

A) BSL-1
B) BSL-4
C) BSL-3
D) BSL-2

5. A patient with a prosthetic joint develops a chronic infection. Multiple synovial fluid cultures grow a Gram- positive coccus that forms a biofilm and is resistant to multiple antibiotics, including methicillin and gentamicin. The MOST likely organism is:

A) Staphylococcus aureus
B) Staphylococcus epidermidis
C) Streptococcus agalactiae
D) Enterococcus faecium

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